منابع مشابه
Molecular characterization of human tensin.
Tensin is a focal-adhesion molecule that binds to actin filaments and interacts with phosphotyrosine-containing proteins. To analyse tensin's function in mammals, we have cloned tensin cDNAs from human and cow. The isolated approx. 7.7-kb human cDNA contains an open reading frame encoding 1735 amino acid residues. The amino acid sequence of human tensin shares 60% identity with chicken tensin, ...
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Spontaneous histamine release from isolarted Mastcells was found to be independent of calcium in the concentration range up to 1 m. mole/lit. Phosphatidyl serine do not change the effect of calcium on spontaneous release. The activation of anaphyla.ctic histamine release by calcium is potentiated by phosphatidyl serine but the laitter can't do so w1th strontium. Mastcells, pretreated with AT...
متن کاملProgressive Kidney Degeneration in Mice Lacking Tensin
Tensin is a focal adhesion phosphoprotein that binds to F-actin and contains a functional Src homology 2 domain. To explore the biological functions of tensin, we cloned the mouse tensin gene, determined its program of expression, and used gene targeting to generate mice lacking tensin. Even though tensin is expressed in many different tissues during embryogenesis, tensin null mice developed no...
متن کاملAMPK negatively regulates tensin-dependent integrin activity
Tight regulation of integrin activity is paramount for dynamic cellular functions such as cell matrix adhesion and mechanotransduction. Integrin activation is achieved through intracellular interactions at the integrin cytoplasmic tails and through integrin-ligand binding. In this study, we identify the metabolic sensor AMP-activated protein kinase (AMPK) as a β1-integrin inhibitor in fibroblas...
متن کاملPhosphatase and Tensin Homologue: Novel Regulation by Developmental Signaling
Phosphatase and tensin homologue (PTEN) is a critical cell endogenous inhibitor of phosphoinositide signaling in mammalian cells. PTEN dephosphorylates phosphoinositide trisphosphate (PIP3), and by so doing PTEN has the function of negative regulation of Akt, thereby inhibiting this key intracellular signal transduction pathway. In numerous cell types, PTEN loss-of-function mutations result in ...
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ژورنال
عنوان ژورنال: American Journal of Respiratory Cell and Molecular Biology
سال: 2017
ISSN: 1044-1549,1535-4989
DOI: 10.1165/rcmb.2016-0417ed